December 17 – 20, 2018 Invited session at EMR-IBS, Jerusalem, Israel

December 5, 2018 LMU Open Science Center seminar series, Munich, Germany

September 3 – 6, 2018 Invited session at RSS, Cardiff, Wales

August 27 – 30, 2018 Invited session at ISCB, Melbourne, Australia

May 2018 "STRATOS News" Newsletter 1

March 22, 2018 Seminar series of the SFB 876, Dortmund, Germany


September 17 – 21, 2017 Two sessions at the Jahrestagung GMDS, Oldenburg, Germany.

September 5 – 8, 2017 Invited talk at the Gemeinsame Jahrestagung DGEpi, DGMS und DGSMP, Lübeck, Germany:

Willi Sauerbrei for the STRATOS initiative: "The STRATOS initiative, illustrated by issues in Topic group 2: selection of variables and their functional form" PDF

August 28 – September 1, 2017 Two sessions at CEN ISBS joint conference Biometrics & Biopharmaceutical Statistics, Vienna, Austria.

July 9 – 13, 2017 ISCB: Two sessions with talks from STRATOS members, Vigo, Spain.

May 8 – 12, 2017 Invited session at EMR-IBS and Italian Region conference, Thessaloniki, Greece.



28 August - 2 September 2016 Invited Session at HEC 2016 (Health - Exploring Complexity: an Interdisciplinary Systems Approach), Munich, Germany

August 25th 2016 Mini-Symposium at ISCB (International Society for Clinical Biostatistics) in Birmingham, UK

July 10-15, 2016 Invited Session at the 28th International Biometric Conference, Victoria, Canada

  • Title: "Methodological challenges in observational studies - current perspectives and future directions in functional form, measurement error and causal inference"
  • Organizer: James Carpenter

July 3-8, 2016 1st General Meeting of the STRATOS members at the Banff International Research Station (BIRS), Banff, Canada.

  • Title: "Developing a Comprehensive, Integrated Framework for Advanced Statistical Analyses of Observational Studies"
  • Official BIRS report - PDF



Wednesday August 26, 2015 Invited Session at ISCB 2015, Utrecht, The Netherlands (Abstracts STRATOS).

1) Scientific session 9.00-11.00

Katherine Lee, Melbourne, AUS Regression modelling with missing data: principles, methods, software and examples PDF

Stephen Evans, London, UK STRengthening Analytical Thinking for Observational Studies: the STRATOS initiative: study design PDF

Aris Perperoglou, Essex, UK Multivariable regression modelling using splines. A review of available packages in R  PDF

Terry Therneau, Minnesota, US The STRATOS survival task group PDF

2) During the lunchbreak on Wednesday

12.35 - 13.15 General information, public meeting 13.15 - 13.55 Closed meeting, for members only



Wednesday, 27th August 2014

STRATOS had a scientific session and a session discussing future steps (Abstracts STRATOS).

1) Scientific session 9.00-11.00

STRATOS (Strengthening Thinking about Analyses of Observational Studies) initiative: first results & future steps

Organizers: Willi Sauerbrei, D, and Harbajan Chadha‐Boreham, CH

Willi Sauerbrei, Freiburg, D Introduction PDF

Marianne Huebner, East Lansing, USA Setting the stage with initial data analyses Video (includes Introduction by Willi Sauerbrei) PDF

Ewout Steyerberg, Rotterdam, NL Evaluation of incremental value of a marker: a historic perspective on the Net Reclassification Improvement Video PDF

Michal Abrahamowicz, Montreal, CAN Review of methods used in recent observational epidemiological studies to select variables and their functional forms (STRATOS Task Group 2) Video PDF

Els Goetghebeur, Gent, B Causal questions and principled answers: a guide through the landscape for practicing statisticians Video PDF

2) During the lunchbreak on Wednesday

12.35 - 13.15 General information, public meeting 13.15 - 13.55 Closed meeting, for members only



The STRATOS initative was launched at a half-day Mini-Symposium on the last day of the ISCB2013 meeting in Munich, in August 2013.


There were three general talks by Willi Sauerbrei PDF, Doug Altman PDF and James Carpenter PDF. James also introduced a route map by using TG1 (missing data) as an example.

In addition, there were specific talks discussing key issues of TG2 through TG7:

  • TG2 Selection of variables and functional form, Michal Abrahamowicz PDF
  • TG3 Descriptive and initial data analysis, Saskia Le Cessie PDF
  • TG4 Measurement error, Helmut Küchenhoff PDF
  • TG5 Design, Doug Altman PDF
  • TG6 Evaluating diagnostic tests and prediction models, Petra Macaskill PDF
  • TG7 Causal Inference, Els Goetghebeur PDF