STRATOS mini-symposium at ISCB 2025, August 24-28, Basel Switzerland
Mini-Symposium 3: Statistical Research needs to improve – on the important roles of simulation studies and guidance for analysis
Date: Thursday morning, August 28, 2025
Organizers: Anne-Laure Boulesteix, Willi Sauerbrei
Session 1 (09:00-10:30): Phases of methodological research; Chair: Anne-Laure Boulesteix
09:00-09:20 Georg Heinze (Medical University of Vienna, Austria): How Biostatistical Methods Mature: Understanding the Four Phases of Methodological Research
09:20-09:40 Michal Abrahamowicz (McGill University, Montreal, Canada): Phases of development of the Weighted Cumulative Exposure modeling
09:40-10:00 Willi Sauerbrei (Medical Center - University of Freiburg, Germany): Phases of development of the Multivariable Fractional Polynomial Interaction (MFPI) approach
10:00-10:20 Ewout Steyerberg (University Medical Center Utrecht, Netherlands): Will Net Benefit trump Net Reclassification Index as a measure for incremental value of markers in prediction models? A historical perspective
10:20-10:30 Discussion
Session 2 (11:00-12:30): Talks from TGs and panels; Chair: Willi Sauerbrei
11:00-11.23 Rima Izem (Novartis, Basel, Switzerland) for TG5: Mission impossible? Specifying target estimands for long-term risks and benefits of novel therapies
11:23-11:45 Carsten Oliver Schmidt (University of Greifswald, Germany) for TG3: An overview on recent works and activities of the STRATOS topic group TG3 “Initial data analysis”
11:45-12:08 Sabine Hoffmann (Ludwig-Maximilians-Universität Munich, Germany) for the open science panel: An overview and recent developments of the STRATOS Open Science panel
12:08-12:30 Aris Perporoglou (GSK, London, UK) for TG2/TG4: Adjusting for Covariate Measurement Error in Non-Linear Regression: Comprehensive Phase 2 Results from the STRATOS TG2-TG4 Study