ISCB 46, Basel, Switzerland

STRATOS mini-symposium at ISCB 2025, August 24-28, Basel Switzerland

Mini-Symposium 3: Statistical Research needs to improve – on the important roles of simulation studies and guidance for analysis

Date: Thursday morning, August 28, 2025 
Organizers: Anne-Laure Boulesteix, Willi Sauerbrei

Session 1 (09:00-10:30): Phases of methodological research; Chair: Anne-Laure Boulesteix

09:00-09:20    Georg Heinze (Medical University of Vienna, Austria): How Biostatistical Methods Mature: Understanding the Four Phases of Methodological Research

09:20-09:40    Michal Abrahamowicz (McGill University, Montreal, Canada): Phases of development of the Weighted Cumulative Exposure modeling

09:40-10:00    Willi Sauerbrei (Medical Center - University of Freiburg, Germany): Phases of development of the Multivariable Fractional Polynomial Interaction (MFPI) approach

10:00-10:20    Ewout Steyerberg (University Medical Center Utrecht, Netherlands): Will Net Benefit trump Net Reclassification Index as a measure for incremental value of markers in prediction models? A historical perspective

10:20-10:30    Discussion


Session 2 (11:00-12:30): Talks from TGs and panels; Chair: Willi Sauerbrei


11:00-11.23    Rima Izem (Novartis, Basel, Switzerland) for TG5: Mission impossible? Specifying target estimands for long-term risks and benefits of novel therapies

11:23-11:45    Carsten Oliver Schmidt (University of Greifswald, Germany) for TG3: An overview on recent works and activities of the STRATOS topic group TG3 “Initial data analysis”

11:45-12:08    Sabine Hoffmann (Ludwig-Maximilians-Universität Munich, Germany) for the open science panel: An overview and recent developments of the STRATOS Open Science panel

12:08-12:30    Aris Perporoglou (GSK, London, UK) for TG2/TG4: Adjusting for Covariate Measurement Error in Non-Linear Regression: Comprehensive Phase 2 Results from the STRATOS TG2-TG4 Study

Program with abstracts

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