Bios Steering Group

Willi Sauerbrei

Dr. Sauerbrei is a senior statistician and professor in medical biometry at the Center for Medical Biometry and Medical Informatics, Medical Center – University of Freiburg, Germany. Since 1983 he has worked as an academic biostatistician with main interest in various issues of model building and in cancer research, with a particular concern for breast cancer. For 16 years he was the heas of a Clinical Trials Unit serving as a data and statistical center for national and international trials in oncology. With Patrick Royston he has developed the multivariable fractional polynomial approach (MFP) and extensions of it that is also subject of a book on multivariable model-building. MEthodological topics of interest include variable and function selection, model stability, treatment covariate interactions, time dependent effects in survival analysis, meta-analysis, reporting of research findings and high-dimensional data. He is the initiator and chair of the STRATOS (STRengthening Analytical Thinking for Observational Studies) intitiative.

 

Michal Abrahamowicz

Dr. Michal Abrahamowicz is a James McGill Professor of Biostatistics at McGill University, in Montreal, Canada. His statistical research aims at development and validation of new, flexible statistical methodology, with main focus on time-to-event (survival) analyses of prognostic and pharmaco-epidemiological studies. He has also developed new methods to control for different sources of bias in observational studies. His collaborative research includes arthritis, cardiovascular, cancer epidemiology. He is the Nominated Principal Investigator on a major grant from the Drug Safety & Effectiveness Network (DSEN) of the Canadian Institutes for Health Research that develops new methods for longitudinal studies of drug safety and comparative effectiveness, and includes >35 faculty members from 14 universities across Canada. He published >290 peer-reviewed papers, and supervised 19 PhD and 14 MSc students, and 7 post-doctoral fellows. He is the co-chair of the international STRATOS initiative. In 2010-14 he was a member of the Executive Committee of ISCB.

 

Marianne Huebner

Marianne Huebner is Associate Professor of Statistics and Probability at Michigan State University. After receiving a PhD in Applied Mathematics she also stayed at UC Berkeley, the Mathematical Sciences Research Institute in Berkeley, and worked at Mayo Clinic. She develops and applies statistical models motivated by scientific questions, specifically in the ares of colorectal, lung and breast cancer, and cardiovascular health. Her research interests include health outcomes research, electronic health records, survival analysis, initial data analyses, and statistical genomics. She is teaching both undergraduate and graduate level courses, some with online components.

 

James Carpenter

James Carpenter is Professor of Medical Statistics at the London School of Hygiene and Tropical Medicine, and Programme Leader in Methodology at the MRC Clinical Trials Unit. His research interests include missing data and sensitivity analysis, meta-analysis and hierarchical modeling, with applications in clinical trials and epidemiology.

Email: James.Carpenter@lshtm.ac.uk. Web: www.missingdata.org.uk

 

Gary Collins

Dr. Gary Collins is an Associate Professor, Head of Prognosis Methodology and Deputy Director of the CSM. His research interests are primarily focused on aspects surrounding the development and validation multivariable prediction (prognostic) models (design and analysis) and he has publishes extensively in this area. He is also interested in the systematic review and appraisal of prognostic studies and is an author of the CHARMS Checklist for conducting systematic reviews of predicition modelling studies.

Gary is interested in the reporting of health research studies and in 2015 was invited to be a UK EQUATOR Centre Fellow. Along with Doug Altman, Karel Moons and Hans Reitsma, UMC Utrecht, the Netherlands, he led an international collaboration to produce the TRIPOD consensus guidance on issues to report when developing or validating (prognostic and diagnostic) prediction models. He is also a member of the GATHER working group, which is developing guidance for reporting global health estimates.

Gary has more than 120 peer-reviewed articles, editorials and commentaris, including 18 in the ‘Big 6’ general medical journals, and is the first or senior author of more than 50 articles. He is a Statistical  Editor (‘hanging commitee’) for the British Medical Journal (since 2010), an Associate Editor for Research Integrity and Peer Review, and BMC Medical Research Methodology, and an Academic Editor for both PeerJ and PLoS One.